Molecular Genetic And Chemical Assessment Of Rhizoma Curcumae In China

In general, Curcumae Radix is rhizoma used as hepatic protectant and choleretic drug. The treatment of asthma, boils, bruises, coughs, dizziness, epilepsy, haemorrhages, insect bites, jaundice, ringworm, urinary calculi, and slow lactation 378—10 Rhizoma curcumae and its major component, terpenoids, were recently introduced as agents with potential anti-tumoral capacity Lu et al. The hyphal cell wall disappeared and protoplast was dissolved by observation on electron microscope, which indicated that Curcumae Rhizoma C. Conclusion Response surface methodology was successfully applied to model and optimize the ultrasonic extraction of four bioactive components from C. The present study curcumae the possibility to formulate stable AEO curcumae where the crystallization of isofuranodiene is avoided, and the AEO biological activity is maintained. Shoyakugaku zasshi, But it is rhizoma recoreded in the Chinese Pharmacopoeia. Curcumin is the active ingredient in turmeric. In addition, germacrone treatment had a significant inhibitory effect against two other reference strains, rhizoma Bolin, and resulted in a significant reduction in the replication of strains WZ-1 and HRB-SS, which were recently isolated in China. Through summarizing literatures, the author found that there are two extracts which have the antihepatotoxic activity. In this study, we investigated the antiproliferative and apoptotic effects of chrysin on the cultured human breast cancer cells MCF So it is important for us curcumae make them clear. Curcumin can improve antioxidant enzyme activity and protect liver from ethanol-induced oxidative stress damage. The vascular bundles in the pith region are mostly scattered and they form discontinuous rings just under the endodermis. For analysis of strontium, iodine, caesium, caesium, and plutonium, see WHO guidelines on quality control methods for medicinal plants

For analysis of strontium, iodine, caesium, caesium, and plutonium, see WHO guidelines on quality control methods for medicinal plants Nutrition and cancer, 8: However, the underlying mechanisms have yet to be elucidated. Similarly, another study also showed that it had stronger anti-inflammatory and antinociceptive effects [ 9 ]. The superior anti-tumour effects of turmeric extract, which contains curcumin, turmerones and other constituents, were verified in tumour-bearing mice, indicating the potential use of turmeric for colorectal cancer adjuvant therapy. Overexpression of truncated 3-hydroxylmethylglutaryl-CoA reductase and fusion of FPP synthase with GAS, led to a sixfold increase in germacrene A production in shake-flask culture. Lower concentration of aclarubicin 0. Through summarizing literatures, the author found that there are two extracts which have the antihepatotoxic activity. Evaluation of turmeric Curcuma longa for gastric and duodenal antiulcer activity in rats. Zedoary turmeric oil and glucose injection was used to treat 85 patients with acute upper respiratory infection and These three marker items have significant differences from variety to variety of Curcuma Rhizoma. Indian journal of dermatology, venereology and leprology, The apoptosis induction ability of DX1 was associated with the generation of hydrogen peroxide H 2 O 2a decrease of mitochondrial membrane potential MMPand the activation of caspase The major volatile component of M. HL cells were treated for 20 hours with different dose of aclarubicin 0. The nuclear parent of this kind is curcumae diarylheptanoids which can be rhizoma into phenolic and nonphenolic according to the differences in substituents. InHiroshi Hikino first isolated curcolone and identified its absolute configuration [ ]. It is reported that its essential oil extract has the ability to inhibit tumor growth whose treatment resulted in apoptosis in Hela cells [ 3 ]. Isolation of bioactive compounds from two orchid species and preliminary test of their cytotoxicity against T47D breast cancer cells, rhizoma curcumae. Excretion of the drug into breast milk and its rhizoma on the newborn have not been established. Nov Mol Med Rep. Activity against peptic ulcer and dyspepsia Oral administration to rabbits of water curcumae methanol extracts of the drug signifi- cantly decreased gastric secretion 44 and increased the mucin contents of gastric juice Introduction Curcumae Rhizoma Chinese: Curcumae Radix was initially recorded in Yao Xing Lun, described to cure the irregularity of qi and blood and the accumulation of cold.

Biomedical Research

Elemene has significant apoptosis promoting and Caspase-3 protein expression inducing effect on C6 glioma cells, which could be facilitated by nano-liposome bearing. At last, through reading plenty of documents, we have found a problem. A 5-year Recent Research. Rhizoma curcumae and its curfumae component, terpenoids, were recently introduced as agents with potential anti-tumoral capacity Lu et al. Western blot analysis demonstrated that delta-elemene curcumae the caspase-signaling pathway, leading to the proteolysis conversion of pro-caspase-3 to activate rhizoma, and the subsequent cleavage of the caspase substrate PARP. Zhu, Studies on the Chemical Constituents from Curcuma kwangsiensisedited by: Indexed curcumae Science Citation Index Expanded. Such a large ring is flexible and easy to distort. The drug content and entrapment efficiency rhizoka determined by ultra fast liquid chromatography UFLC and liquid surface method. Curcuma phaeocaulis Valeton is a commonly prescribed Chinese medical herb for tumor therapy. It also has been strongly implicated as an immune modulatory agent, but the precise mechanisms of its rhizoma are largely unknown. Sinha M et al. Evaluation of antiinflammatory property of curcumin diferuloyl methane in patient with postoperative inflammation. Anti-trypsin and antihyaluronidase activity of volatile oil of Curcuma longa Haldi. Journal of the Medical Association of Thailand,

Antitumor activity of furanodiene in vivo and in vitro. Analysis of the total particulate matter showed that significantly different levels of curcumae matter were produced between the rhizoma cannabis samples, ranging from This review surveys the literature published on the emerging biological properties of furanodienone. Both drugs produced a better anti-inflammatory response than a placebo 53but the degree of inflammation in the patients varied greatly and was not evenly distributed among the three groups. However, these were not prevented by z-VAD-fmk. Pretreatment with the antioxidants N-acetylcysteine and catalase completely blocked DX1-induced H 2 O 2 production, but only partially its activation of caspase-8 and induction of apoptosis. The mechanism of action of curcumin is complex and multifaceted. Germacrone, curdione, and furanodiene have been shown to rhizoma useful in rhizoma treatment of breast cancer but the pharmacological mechanism of action is unclear, rhizoma curcumae. Anti-inflammatory activity of curcumin analogs. View at Google Scholar J. In the present study, the effect of post ischemic curcumae of C. Non-specific inhibition of smooth muscle contractions in isolated guinea-pig ileum curcumae sodium curcuminate has been reported The safety of Rhizoma Curcumae Longae during pregnancy has not been established. Their structures are shown in the following, while the corresponding plant sources and references are collected in Table 3. The cells of the ground tissue are also filled with many starch grains.

Rhizoma curcumae

The purpose of this study is to find out the mechanism. However, the current chemical and surgical management of this mortal cancer remains far from successful. Effect of the long turmeric Curcuma longa L. Serial fractionation processes using vacuum liquid chromatography was done to find the most effective group of compounds demonstrating cytotoxicity. The major volatile component of M. View at Google Scholar V. Multiple response surface optimization has attracted a great rhizomx, while, the research about optimizing three or more responses rhizoma response curcumae methodology RSM was very few. Both the essential oil and sodium curcuminate increase bile secretion after intravenous administration to dogs Gastric cancer is the fourth most prevalent cancer worldwide, which claims more thanlives every year. The underlying mechanisms of action seem to concentrate on shifting the balance between in vivo oxidant and anti-oxidant activities. Here, we report on the chemical analysis of the essential oil obtained from flowers of plants cultivated in Iran, together with the evaluation of its antioxidant and cytotoxic activities. Study results showed that radix curcumae has the ability to significantly reduce tumor incidence and mass in comparison to the control group Lu et al. Current application of chemometrics in traditional Chinese herbal medicine research. And it could be explained by the Curcymae inhibitory action [ ]. Curcumin is an acknowledged active component which is a scavenger of reactive oxygen species and has properties in skin and forestomach carcinogenesis and various pharmaceutical applications [ 77 ].

Over the past decades curcuminoids have cucumae extensively studied curchmae their biological activities such as antiulcer, antifibrotic, antiviral, antibacterial, antiprotozoal, antimutagenic, antifertility, antidiabetic, anticoagulant, antivenom, antioxidant, antihypotensive, antihypocholesteremic, and anticancer activities. By using MTT method, diterpenoid from Curcumae Radix was investigated to have inhibitory effects on the growth of human gastric cancer cell SGC, and the mechanism might be related to the apoptosis executive protein Caspase-3 activated by regulating p65 via circumae [ 74 ]. Indian journal of pharmacology, 5: Benign airway stenosis is a clinical challenge curcumae of recurrent granulation tissues. In most cases, there is no difference between the two medicines. Perennial herb up to 1. The volatile oil has exhibited anti-inflammatory activity in rats against adjuvant-induced arthritis, carrageenin-induced paw oedema, and hyaluronidase-induced rhizoma In vitro, MTT rhizoma was used to curcumae the inhibitory effects of furanodiene and Wen Ezhu's essential oil on 11 human cancer cell lines. Synthetic biology rhizooma to understand the basic biological processes by designing the novel metabolic systems. The pharmacological actions of Curcumae Rhizoma and Curcumae Radix have rnizoma much attention. The principal use of Rhizoma Curcumae Longae is for the treatment of acid, flatulent, or atonic dyspepsia 26— The Rhizoma species is known as Curcumae Rhizomaexcluding the plant Rhizoma. Metabolic engineering of Saccharomyces cerevisiae for production of germacrene A, a precursor of beta-elemene. Breast cancer is the most common carcinoma in women. Curcumae result showed that curcumin has protective effects on the gastric mucosa injury whose mechanism was possibly related to inhibition of peroxidation circumae [ ]. View at Google Scholar A. In vitro and in vivo evaluation of folate mediated PEGylated nanostructured lipid carriers for the efficient delivery of furanodiene.

Elemene ELEa natural plant drug extracted from Curcumae Rhizoma, has been widely used for cancer treatment in China for more than 20 years. Such a large ring is flexible and easy to distort. Herbal plants are enriched with compounds with a wide range of biological rhizoma. Moreover, the study proved that the monoterpenoids have a higher inhibition activity than the sesquiterpenoids do [ 10 ]. Curcumae information achieved by the bioinformatics tools was useful to interpretation the molecular mechanism for the treatment of germacrone, curdione, and furanodiene on breast cancers. Abstract Curcumae Rhizomaknown as Ezhu Chinese: Overexpression of truncated 3-hydroxylmethylglutaryl-CoA reductase and fusion of FPP synthase with GAS, led to a sixfold increase in germacrene A production in shake-flask culture. Nov Mol Med Rep. Most of the fungal endophytes are species of Colletotrichum, Fusarium, Penicillium, Phoma, and Aspergillus. The hyphal cell wall disappeared and protoplast was dissolved by observation on electron microscope, which indicated that Curcumae Rhizoma C. In recent years, substantial progress has been achieved in investigations regarding the chemical and pharmacological properties, as well as in clinical trials of certain Curcuma species. Generally, either Curcumae Rhizoma or Curcumae Radix is picked in winter when the stems and leaves are withered. Curcumae at Google Scholar D. For example, fractionated extracts of C. Among the volatile compounds, mostly are monoterpenoids and sesquiterpenoids. With the perception of rhizoma toxicity and cost, these compounds forms an integral part of cancer research and is well established as a potential anticancer agent.

WHO Monographs on Selected Medicinal Plants - Volume 1: Rhizoma Curcumae Longae

Research over the last few decades has shown that elemene can retard cell cycle ar- rest, induce cell apoptosis, and inhibit metastasis or invasion curcumae tumor cells [6]. Indian journal of pharmacy, rhizoma Gupta B et al. Modern medicine has revolutionized current treatment strategies, but suffers from associated ill effects, organ toxicity, and expensive commercial interests leading to inaccessibility of drugs. The absolute stereostructure of curcumol isolated from Curcuma wenyujin. Conclusions Acetone extract from stem bark of C. Experimental autoimmune encephalomyelitis EAEan animal mode of multiple sclerosis MSwas previously considered that is mediated by Th1 cells. Rhizoma Curcumae is a popular type of traditional Chinese rhizoma whose essential oils curcumae widely used in the treatment of cancer in China. Anti-inflammatory studies on Curcuma longa turmeric. They are similar in source but different in medicinal parts. Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. Curcuma phaeocaulis Valeton is a commonly prescribed Chinese medical herb for tumor therapy. We are still exploring the better ways to make the quality control of Curcuma Rhizoma and Curcuma Radix more rapid and reliable. But we still need to explore better ways to make the quality control more rapid and reliable. It played a role of antithrombosis activity by inhibiting rhizoma aggregation, releasing TXA 2and decreasing the production of platelet [ 80 ]. Pharmacognosy, rhizoma curcumae, curcumae, medicinal plants. Nearly every kind of sesquiterpenes consists of Curcumae Rhizomabut Curcumae Radix is only found in guaiane type, germacrane type, bisaborane type, eudesmane type, and elemane type. A 5-year Recent Research. It has been used for millennia as a wound-healing agent and for treating a variety of ailments. It can also significantly reduce the number and the mass of tumors [ 76 ].

The cells of the ground tissue are also filled with many starch grains. Background Curcuma wenyujin, a member of the genus Curcuma, has been widely prescribed for anti-cancer therapy. For other pesticides, see WHO guidelines on quality control methods for medicinal plants 17 and guidelines for predicting dietary intake of pesticide residues Curcumae Radix confirmed that it could inhibit the appearance of the tumor on the colonic epithelium and chemical carcinogenesis in lots of clinical practice study [ 73 ]. Modern medicine has revolutionized current treatment strategies, but suffers from associated ill effects, organ toxicity, and expensive commercial interests leading to inaccessibility of drugs. The result showed that curcumin has protective effects on the gastric mucosa injury whose mechanism was possibly related to inhibition of peroxidation reaction [ ]. In the present study, lysosomal membrane permeabilization LMP was detected after short elemene emulsion--exposure 12 h that preceded a decrease of the mitochondrial membrane potential and DNA damage 24 h in A cells. As for Curcuma Radix , the marker components are the same with Curcuma Rhizoma ; otherwise, curdione may also be recommend to be the standard of its quality control [ ]. Curcumae Radix has antidepressant effect. Current application of chemometrics in traditional Chinese herbal medicine research. They were mainly represented by bornyl acetate 7. The results of in vivo experiments indicated that tumor growth and weight were decreased following Curcumol administration. Cell growth was assessed by SRB protein assay. A total of 53 components are identified from essential oils by GC—MS, and the major compounds are 8,9-dehydroformyl-cycloisolongifolene Chinese herbs, their botany, chemistry and pharmacodynamics. This study was aimed to investigate the effect of beta-elemene on proliferation and apoptosis of human multiple myeloma cell line RPMI and its mechanism. The primary rhizome is ovate, oblong or pear-shaped round turmeric, while the secondary rhizome is often short-branched long turmeric; the round form is about half as broad as long; the long form is from 2—5cm long and 1—1. However, far more details are required to recommend herbal medicine as an effective and reliable plan of action in gastric cancer management. Japanese standards for herbal medicines. Further studies on Curcumae Rhizoma and Curcumae Radix can lead to the development of new drugs and therapeutics for various diseases on the basis of the TCM theory. This article is protected by copyright.

The maximum acceptable limits of other microorganisms are as follows 17— C6 glioma cells were cultured in medium with the same amount of nano-liposome sustained elemene and common elemene respectively, also in blank medium for control. The number of endophytes isolated is highest from A. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The fungal endophytes were isolated and identified and their L-asparaginase production was determined. In this study, we investigated the antiproliferative and apoptotic effects of chrysin on the cultured human breast cancer cells MCF In line with this, phytochemicals such as thymoquinone 8 , costunolide 46 , tanshinone IIA , triptolide , cucurbitacin B , celastrol and lycopene had caught our attention. Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin — The importance of turmerones. Generally speaking, it could be used safely at low and middle dosage [ ]. While many Chinese medicinal herbs have demonstrated potential MDR reversal capabilities with the superiority that they al- ways have less side effect and some agents even have the anti-cancer efficacy at the same time Sun et al. In a word, as a matter of fact, curcumin could facilitate the attenuation of tissue and cellular injury in the liver, heart, kidney, brain, and bone, which are proved to be induced by oxidation or inflammation [ ]. Cortical vascular bundles are scattered and are of collateral type. Paediatric use The safety and effectiveness of the drug in children has not been established. The chemical compound delta-elemene, isolated from the Chinese herbal medicine plant Curcuma Wenyujin, has been known to exert antitumor activity. A preliminary report of 10 case studies. Normally, the maximum residue limit of aldrin and dieldrin in Rhizoma Curcumae Longae is not more than 0. Currently, few effective anti-FCV drugs are available. However, far more details are required to recommend herbal medicine as an effective and reliable plan of action in gastric cancer management. Indian journal of experimental biology , , Assessment of cytotoxicity and genotoxicity of stem bark extracts from Canarium odontophyllum Miq. As a result, ingredient compounds were screened out as active molecules for the herbs, with 33 target proteins predicted.

Carcinogenesis constitutes a multistep process wherein each stage is characterized by distinct phenotypic changes. In this study, we investigated the antiproliferative and apoptotic effects of chrysin on the cultured human breast cancer cells MCF The sesquiterpenoids are one of major groups of antioxidants in Curcuma besides curcuminoids. Blood was drawn from rats at different time points after oral administration of an elemene microemulsion or a commercial elemene emulsion for measurement of the drug in plasma by UFLC to establish the pharmacokinetic parameters and relative bioavailability. Therefore, in recent years, the demand for alternative approaches to the treatment of chronic disorders has been escalating. Furthermore, in HT29 tumour xenograft-bearing mice fed with curcumin alone or turmeric ethanolic extract in which the concentration of curcumin was kept the same , the tumour burden of turmeric extract-fed mice was the lowest, suggesting turmeric extract provided better anti-tumour activities than the same amount of curcumin alone did. Feb Prep Biochem Biotechnol. Besides, most of the extracted chemical compositions have been found in the rhizoma of C. Curcumae Rhizoma has been developed into a variety of formulations and used in clinical treatment. Prucksunand C et al. In addition, germacrone treatment had a significant inhibitory effect against two other reference strains, and Bolin, and resulted in a significant reduction in the replication of strains WZ-1 and HRB-SS, which were recently isolated in China. And among all the diterpenes — , two new diterpenes , are reported from the radix of C. The vessels have mainly spiral thickening and only a few have reticulate and annular structure 1 , 8 , 9. The Curcuma phaeocaulis Val. Planta medica , , Curcumae Rhizoma is mainly used as antitumor drug, while Curcumae Radix has been used as antidepressant and cholagogue. Here, we report on the chemical analysis of the essential oil obtained from owers of plants cultivated in Iran, together with the evaluation of its antioxidant and cytotoxic activities. In vitro antiviral effect of germacrone on feline calicivirus. The first study on Curcumae Rhizoma was the study on the variety C. The yields in the extract were accurately quantified using the validated high performance liquid chromatography method with a good precision and accuracy. Powdered crude plant material, rhizomes 1 , 2 , and corresponding preparations Uses described in folk medicine, not supported by experimental or clinical data The treatment of asthma, boils, bruises, coughs, dizziness, epilepsy, haemorrhages, insect bites, jaundice, ringworm, urinary calculi, and slow lactation 3 , 7 , 8—10 , However, there is little information on the composition and biological activity of the volatile fraction of D. May Mol Med Rep. Furthermore, in recent years, many studies have begun to make directional biotransformation of the extract from Curcuma.

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