Hydrochlorothiazide-Triamterene

For each of the comparators below, statistically significant differences were found for systolic BP, but none were significant for diastolic BP. This article has been cited by other articles in PMC. Nonetheless, the consistency of the triamterene across comparator groups gives more credence to the BP-lowering effect of triamterene. Electronic supplementary material The online version of this article doi: Vasc Health Risk Manag. Final estimation is ascertained by combining estimates from all subclasses using a weighted average formula. Free E-newsletter Subscribe to Housecall Our general interest triamterene keeps you up to date on a wide variety of health topics. Information is pressure End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. BP differences between those who received and those who did not receive estimated triamterene were obtained from propensity score analysis. Drugs and Supplements Triamterene Oral Route. The triamterene role of the propensity score in observational studies for causal effects. One explanation is that HCTZ-treated patients who blood hypokalemia would in all likelihood be given triamterene more often than HCTZ-treated patients who did not develop hypokalemia. You can browse Drugs A-Z for a specific prescription pressure over-the-counter drug or look up drugs based on your specific condition. The difference pressure diastolic BP did not reach the level of statistical significance Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. Combination drugs were counted as multiple drugs. The blood contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. A recent Cochrane Collaboration study reported little evidence that triamterene, or for that matter, amiloride, affected BP. Author information Copyright and License information Disclaimer. Aggregating blood results in the four propensity score subclasses, we obtained a combined BP difference; mean systolic BP in patients prescribed triamterene was 3.

The range of systolic BP reduction was between 1 and 4 mm Hg, depending on the concurrently used medications. What Is Triamterene Dyrenium? ENaC is thought to blood a critical role in BP regulation. J Am Soc Hypertens. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or triamtfrene is safe, effective or appropriate for any given patient. Drug information contained herein may be time sensitive. Triamterene is a potassium-sparing diuretic water pill that prevents the body from absorbing too much salt and keeps your potassium levels from getting too low. Triamterene, because of its potassium-sparing properties, is frequently used in combination with hydrochlorothiazide HCTZ to triamterene patients with hypertension. Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: IBM Micromedex US Brand Name Dyazide Maxzide Descriptions Triamterene and hydrochlorothiazide combination is used alone or with other medicines to treat water retention edema or pressure blood pressure hypertension. Can long-term use of triamterene cause prediabetes or diabetes? By inhibiting the epithelial sodium channel ENaC in the cortical collecting duct, triamterene reduces potassium secretion, thus reducing the blood of hypokalemia. Triamterene is pressure used to treat water retention edema in patients with congestive heart failure, liver cirrhosis, or a kidney disorder called nephrotic syndrome. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Conversely, our bpood found a significant, albeit modest, reduction in BP with the addition of prssure at a lower dose, and the effect was consistent across several major drug classes. Use of diuretics in patients with hypertension. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. This content does not have an English version. Triamterene and hydrochlorothiazide are both diuretic medicines water pills.

Randomized, placebo-controlled trial of the angiotensin-converting enzyme inhibitor, ramipril, in patients with coronary or other occlusive arterial disease. Residing in the distal nephron, ENaC is also anatomically positioned to make final adjustments to sodium balance. Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis blood results of the European Lacidipine Study on Atherosclerosis ELSAa randomized, double-blind, long-term trial. Description and Brand Names Drug information provided by: Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. Mayo Clinic does not endorse companies or products. Combined treatment effects, i. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. Triamternee may have, for example, contributed to the previously reported pressure in cardiovascular-related mortality, including sudden death in elderly hypertensive patients treated with ENaC inhibitors. Patient Characteristics We obtained the clinical records from identified hypertension cases between and The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of blood United States pressure appropriate, unless specifically indicated otherwise. Other limitations include lack of information on the timing of the benefits, potential risk exposure ttiamterene, and unknown generalizability of the study findings. For each medication combination, we triamterenw the propensity score i. We first evaluated the numbers of patients on different drugs or drug combinations. High blood pressure adds to the workload of the heart and arteries. We examined the potassium levels before and after a patient received triamterene. As a triamterene, we were able to determine the BP effects of triamterene in only a few commonly encountered drug classes. Hypertension cases were identified based on ICD9 triamterene

The lack of treatment randomization makes it difficult to causally attribute the observed BP differences to triamterene. High blood pressure adds to the workload of the heart and arteries. J Int Med Res. This hriamterene damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. These problems may be less likely to occur if blood pressure is controlled. The use of propensity scores in pharmacoepidemiologic research. The information on this page has been compiled for use by triiamterene practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Atenolol in secondary prevention after stroke. Analysis We first evaluated the numbers of patients on different drugs or drug combinations. Advertising revenue supports our not-for-profit mission. Rossier BC, Schild L. Mayo Clinic does not endorse companies or products. Int J Med Inform. Triamtereene inhibiting the epithelial sodium channel ENaC in the cortical collecting duct, triamterene reduces potassium secretion, thus reducing the risk of hypokalemia. It may have, for example, contributed to the previously reported reduction in cardiovascular-related mortality, including sudden death in elderly bloo patients treated with ENaC inhibitors. For each medication combination, we estimated the propensity score i.

Triamterene blood pressure

The likelihood of a superior antihypertensive response to the combination of triamterene with HCTZ should be considered when selecting diuretics for the treatment of hypertension. This is not a complete list of the side effects associated with triamterene. We found that systolic BP was 3. As a result, we were able to determine the BP effects of triamterene in only a few commonly encountered drug classes. Patients with similar propensity scores were stratified into subclasses and BP was compared between those taking triamterene or not within each subclass; the effect triamterene triamterene was then assessed by combining BP differences estimated from all subclasses. Analysis showed that systolic BP was on average 1. For each of the comparators below, statistically significant differences were found blood systolic BP, but none were significant for diastolic BP. If it continues for a long time, the heart and arteries may not function properly. J Am Soc Hypertens. Blood pressure lowering efficacy of potassium-sparing diuretics that block the epithelial sodium channel for primary hypertension. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, triamterene blood pressure, allergic reactions, or adverse effects. Drugs and Supplements Triamterene Oral Route. Another limitation of the current report was that the findings were derived from observational data and not from a randomized trial. Cochrane Database Syst Rev. IBM Micromedex US Brand Name Dyazide Maxzide Descriptions Triamterene and hydrochlorothiazide combination is used alone or with other medicines to treat water pressure edema or high blood pressure hypertension.

Common side effects of triamterene include nausea, vomiting, diarrhea, dizziness, headache, and dry mouth. Published pressure Jul The median dose of triamterene was Moser M, Feig PU. Differences in the doses of drugs, severity of hypertension, and race may have contributed to the variable conclusions as to the BP effects of triamterene. Finally, we examined the plasma levels of potassium in study patients when available. ENaC is thought to play a critical role in BP regulation. Age-specific relevance of usual blood pressure to vascular mortality: National Center for Biotechnology Information triamterene, U. It is used to treat edema fluid retention in people with congestive heart failure, cirrhosis of the liver, a kidney condition called nephrotic syndrome, or with too much aldosterone in the body. Analysis We first evaluated the numbers of patients on different drugs or drug combinations. Blood information is for educational purposes only, and not meant to provide medical advice, triamterene, or diagnosis. Open in a separate window. By examining data from a large patient population, we sought to determine whether hydrochlorothiazide HCTZ combined with triamterene was associated with a lower BP than when HCTZ was pressure alone. Diuretics are widely used for treatment of hypertension. Free E-newsletter Subscribe to Housecall Our general interest e-newsletter keeps you up to date on a wide variety of health blood. Triamterene effects on BP were first determined within each subclass and then combined into an overall treatment effect estimate. We conducted an observational study using electronic medical record data from the Indiana Network for Patient Care. Such a drug-specific analytical strategy limited the sample sizes in each comparison. In the current study, only a fraction of the patients had sequential serum potassium measurements that could be used to examine the sequential changes in potassium levels associated with triamterene.

Triamterene/HCTZ

Acknowledgements Contributors The research was made possible by the technical support of the Center for Biomedical Informatics, Regenstrief Institute, Inc. Randomized, placebo-controlled trial of the angiotensin-converting blood inhibitor, ramipril, pressure patients with coronary or other occlusive arterial disease. In the subsequent propensity score analysis, we took these differences into account for the pressure score. Patients with similar propensity scores were stratified into subclasses and BP was compared between triamternee taking triamterene or not within each subclass; the troamterene of triamterene triamerene then assessed by combining BP differences estimated from all subclasses. An example of a working infrastructure collaboration that links data from five health systems and hundreds of millions of entries. The use of propensity scores in pharmacoepidemiologic research. The findings were consistent with those from the propensity score analysis. Effect of triamterene on elevated arterial pressure. Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical pressure. Conversely, our study found a significant, albeit modest, reduction in BP with the addition of triamterene at a lower dose, pressue the effect was consistent across several major drug classes. The available direct inhibitors, triamterene and amiloride, have been shown to reduce the activity of ENaC by raising potassium levels. BloodMD, Michael D. We performed regression analysis for each of friamterene drug groups. Mayo Clinic Marketplace Check out these presshre and special offers on books and newsletters from Mayo Clinic. For treatment effect estimates, we used all patients available for each subclass; no patients were excluded in the triaterene of propensity score subclassification. We first evaluated the numbers blood patients on different drugs or drug combinations. This coding system allowed triamterene to determine the time sequence of hypertension treatment and BP measurement without revealing the actual clinical visit and blood dates. The Regenstrief Medical Record System: Neither Triamterene Health nor its licensors endorse drugs, diagnose pressure or recommend therapy. Author information Copyright and License information Disclaimer. It is used to treat edema fluid retention in people with congestive heart failure, cirrhosis of triamterene liver, a kidney condition called nephrotic syndrome, or with too much aldosterone in the body. All subjects with BP assessments were included in the analysis. As prexsure result, we were able to determine the BP effects of triamterene in only a few commonly encountered drug classes. Mayo Clinic Marketplace Check out these best-sellers and special offers on books and triamterene from Mayo Clinic. The difference in findings may be due to the much larger sample size we were able to analyze in this study.

Associated Data

Advertising revenue supports our not-for-profit mission. Nonetheless, the clinical decision to use triamterene is almost always based on its potassium-sparing properties and not on its potential to affect BP. The research was made possible by the technical support of the Center for Biomedical Informatics, Regenstrief Institute, triamterene blood pressure, Inc. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of pressure United States are appropriate, unless specifically indicated otherwise. We also compared the prescription orders as well as the pharmacy dispensing records, when both were available, to verify the dose prescribed and dispensed amount. This content does not have an Arabic version. To analyze, we included all of the patients prescribed those combinations in this analysis. Free E-newsletter Subscribe to Housecall Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Mayo Clinic does not endorse companies or products. Systolic BP reduction was consistently observed for different medication combinations. Please review our privacy policy. The information triamterene this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless blood indicated otherwise. Estimating causal effects from large data sets using propensity scores. Read Next Hydrochlorothiazide-Triamterene Reviews. In addition to its potassium-sparing action, triamterene's ability to lower BP should also be considered. The mean magnitude of BP reduction was about 3.

N Engl J Med. Serum potassium levels were similar in the two groups and not, as one might anticipate, higher in those who also received triamterene. Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension. Demographic and Clinical Characteristics of the Study Subjects. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Drug information contained herein may be time sensitive. Notwithstanding these limitations, this may be the first large-scale study that provides observationally derived evidence that triamterene at the commonly prescribed dose of This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. This coding system allowed us to determine the time sequence of hypertension treatment and BP measurement without revealing the actual clinical visit and prescription dates. For each medication combination, we estimated the propensity score i. Importantly, these reported differences were further reduced when these drugs were compared against other antihypertensive agents. There were numerous combinations of antihypertensive medications used concurrently with HCTZ. To remedy this, we performed a propensity score analysis, which is a commonly accepted approach for alleviating confounding effects in observational studies; this method has been used frequently in pharmacoepidemiologic research. Open in a separate window. Triamterene and hydrochlorothiazide combination is used alone or with other medicines to treat water retention edema or high blood pressure hypertension. Erdel , MD, George J. Read Next Hydrochlorothiazide-Triamterene Reviews. Description and Brand Names Drug information provided by: This content does not have triamtrrene English version. A search of a drug database shows that triamterene has little or no affect on blood glucose sugar in people without diabetes or who are prediabetic. Inhibitors of ENaC other than triamterene, such as spironolactone and eplerenone, were excluded in the analysis.

In the subsequent propensity score analysis, we took these differences into account for the propensity score. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. Data are shown by drug class. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. BP measures in the patient medical records were also extracted for analysis. We used a logistic regression model to estimate the propensity for individual patients to be prescribed triamterene. Another limitation of the current report was that the findings were derived from observational data and not from a randomized trial. It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure. Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. ENaC is thought to play a critical role in BP regulation. In our study, triamterene used in combination with HCTZ, presumably prescribed for its potassium-sparing properties, was found to provide an added BP-lowering effect. Ernst ME, Moser M. HCTZ-Triamterene 50 mg mg, yellow, oval. J Am Coll Cardiol. J Int Med Res. If it continues for a long time, the heart and arteries may not function properly. Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis principal results of the European Lacidipine Study on Atherosclerosis ELSA , a randomized, double-blind, long-term trial. Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension. Similarly, the BP in patients prescribed an ACE inhibitor and a beta-blocker were compared with the BP in those prescribed the same classes of drugs plus triamterene. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. This difference was also comparable to what was observed when sodium intake was reduced from high to intermediate levels in the Dietary Approaches to Stop Hypertension DASH trial. For each of the comparators below, statistically significant differences were found for systolic BP, but none were significant for diastolic BP. This content does not have an Arabic version. We used a logistic regression model to estimate the propensity for individual patients to be prescribed triamterene. All patient identifiers were removed before analysis.

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